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We provide new approximation algorithms for the Red-Blue Set Cover and Circuit Minimum Monotone Satisfying Assignment (MMSA) problems. Our algorithm for Red-Blue Set Cover achieves Õ(m^{1/3})-approximation improving on the Õ(m^{1/2})-approximation due to Elkin and Peleg (where m is the number of sets). Our approximation algorithm for MMSA_t (for circuits of depth t) gives an Õ(N^{1-δ}) approximation for δ = 1/3 2^{3-⌈t/2⌉}, where N is the number of gates and variables. No non-trivial approximation algorithms for MMSA_t with t ≥ 4 were previously known. We complement these results with lower bounds for these problems: For Red-Blue Set Cover, we provide a nearly approximation preserving reduction from Min k-Union that gives an Ω(m^{1/4 - ε}) hardness under the Dense-vs-Random conjecture, while for MMSA we sketch a proof that an SDP relaxation strengthened by Sherali-Adams has an integrality gap of N^{1-ε} where ε → 0 as the circuit depth t → ∞.